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composite(a(CHEBI:epoxomicin), p(HGNC:MAPT))

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Components

Appears in Networks 1

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1

In-Edges 0

Out-Edges 4

composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) hasComponent a(CHEBI:epoxomicin) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) increases bp(GO:"protein ubiquitination") View Subject | View Object

Similarly, a dramatic elevation of ubiquitinated substrates (from 4.2±0.1 to 37±1) upon epoxomicin treatment was detected in dendrites containing MAPT (compare Fig. S4E and Fig. S4F). PubMed:30145931

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Dendrites

composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") View Subject | View Object

MAPT-free dendrites in controls had a spine density of ~17 per 20-µm (17.2±0.5 per 20 µm) length, and there was a ~2- fold decrease in spine density in the MAPT-containing dendrites in neurons treated with wortmannin (7.4±1.0 per 20 µm) or epoxomicin (8.2±1.7 per 20 µm) (Fig. 6D). PubMed:30145931

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.