TLR9

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: TLR9
Namespace: hgnc
Namespace Version: 20180906
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(CHEBI:heme) increases p(HGNC:TLR9) View Subject | View Object

Heme amplifies cytokines induced by cell surface receptors (TLR2, TLR4, TLR5), endosome receptors (TLR3, TLR9), and cytosolic receptors (NOD1 and NOD2). PubMed:24904418

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): macrophage
MeSH: Liver
MeSH: Malaria
Text Location: Review

Out-Edges 1

p(HGNC:TLR9) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): macrophage
MeSH: Plasma
MeSH: Urine
MeSH: Anemia, Hemolytic, Autoimmune
Text Location: Review

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.