1. Catalog
  2. Nodes
  3. a(CHEBI:lactacystin)

a(CHEBI:lactacystin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
lactacystin
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 7

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.0

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1

In-Edges 2

composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) hasComponent a(CHEBI:lactacystin) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) hasComponent a(CHEBI:lactacystin) View Subject | View Object

Appears in Networks:

Out-Edges 10

a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) View Subject | View Object

It has been shown that Abeta can be degraded by the proteasome in cultured neurons and astrocytes, and reatment with the proteasome inhibitor lactacystin decreased viability of cells exposed to Abeta (Lopez Salon et al., 2003). PubMed:14556719

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Cell Ontology (CL)
neuron

a(CHEBI:lactacystin) increases bp(GO:"cell death") View Subject | View Object

It has been shown that Abeta can be degraded by the proteasome in cultured neurons and astrocytes, and reatment with the proteasome inhibitor lactacystin decreased viability of cells exposed to Abeta (Lopez Salon et al., 2003). PubMed:14556719

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Cell Ontology (CL)
neuron

a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) View Subject | View Object

In SH-SY5Y neuroblastoma cells, treatment with lactacystin, a selective inhibitor of the 20S catalytic core, maintained levels of transfected wild-type full-length tau (4R0N) after cycloheximide treatment halted protein synthesis (65). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:lactacystin) increases p(HGNC:MAPT) View Subject | View Object

Additionally, incubation of rat brain extract (containing endogenous tau and proteasomal enzymes) with the proteasome activators Mg2+ and ATP resulted in lower total tau levels with an increase in smaller forms, compared to extract not supplemented with Mg2+ and ATP (73). The loss of tau was blocked by lactacystin giving further evidence that the proteasome was degrading tau (73). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) View Subject | View Object

Similarly, overexpressing the FTDP-17 mutant P301L tau in SH-SY5Y cells and then treating with lactacystin led to significantly increased tau levels (70). Lactacystin also caused accumulation of endogenous tau in the HT22 murine neuronal cell line (71). In immortalized mouse cortical neuronal cells inducibly expressing full-length wild-type tau, EPX slowed the degradation of full-length tau (72). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) View Subject | View Object

Additionally, incubation of rat brain extract (containing endogenous tau and proteasomal enzymes) with the proteasome activators Mg2+ and ATP resulted in lower total tau levels with an increase in smaller forms, compared to extract not supplemented with Mg2+ and ATP (73). The loss of tau was blocked by lactacystin giving further evidence that the proteasome was degrading tau (73). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) View Subject | View Object

Related to these data, reversible and irreversible proteasome inhibitors including lactacystin, leupeptin, and epoxomicin delay the degradation of endogenous and/or transiently overexpressed tau (Cardozo and Michaud, 2002; David et al., 2002; Zhang et al., 2005). PubMed:23528736

Appears in Networks:

a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) View Subject | View Object

Related to these data, reversible and irreversible proteasome inhibitors including lactacystin, leupeptin, and epoxomicin delay the degradation of endogenous and/or transiently overexpressed tau (Cardozo and Michaud, 2002; David et al., 2002; Zhang et al., 2005). PubMed:23528736

Appears in Networks:

a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") View Subject | View Object

Bilateral injection of lactacystin, a specific proteasome inhibitor, into the CA1 region of the rat hippocampus blocks long-term memory formation (Lopez-Salon et al. 2001 PubMed:22908190

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal

a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) View Subject | View Object

In order to determine the impact of protein degradation systems on the sorting of MAPT, we sought to suppress their activity by treating neurons on the neuritic side of the MFCs with either autophagy inhibitors, wortmannin [25] and bafilomycin A 1 [26], or with proteasomal inhibitors, epoxomicin and lactacystin [27,28]. PubMed:30145931

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.