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p(HGNC:APP, frag("1_38"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
APP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 2

complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) View Subject | View Object

gamma-Secretase cleaves APP at multiple sites and in sequential steps to generate Abeta peptides of different lengths (Fig. 1). The majority of Abeta peptides produced are 40 amino acids long, however, peptides ranging from 38 to 43 amino acids are found in vivo PubMed:22122372

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HGNC:APP) hasVariant p(HGNC:APP, frag("1_38")) View Subject | View Object

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.