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a(HM:"Glucose-6-phosphate dehydrogenase deficiency")

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Entity

Name
Glucose-6-phosphate dehydrogenase deficiency
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

path(MESH:Hemolysis) positiveCorrelation a(HM:"Glucose-6-phosphate dehydrogenase deficiency") View Subject | View Object

This common X-linked inherited disorder, characterized by severe intravascular and extravascular haemolysis, is classically triggered by fava bean ingestion or pro-oxidant medications. It causes haemolysis in susceptible individuals and an association with thrombosis was described in multiple case reports (Jewett, 1976; Thompson et al, 2013; Albertsen et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thrombosis) association a(HM:"Glucose-6-phosphate dehydrogenase deficiency") View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation a(HM:"Glucose-6-phosphate dehydrogenase deficiency") View Subject | View Object

This common X-linked inherited disorder, characterized by severe intravascular and extravascular haemolysis, is classically triggered by fava bean ingestion or pro-oxidant medications. It causes haemolysis in susceptible individuals and an association with thrombosis was described in multiple case reports (Jewett, 1976; Thompson et al, 2013; Albertsen et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 4

a(HM:"Glucose-6-phosphate dehydrogenase deficiency") increases path(MESH:Hemolysis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

a(HM:"Glucose-6-phosphate dehydrogenase deficiency") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

This common X-linked inherited disorder, characterized by severe intravascular and extravascular haemolysis, is classically triggered by fava bean ingestion or pro-oxidant medications. It causes haemolysis in susceptible individuals and an association with thrombosis was described in multiple case reports (Jewett, 1976; Thompson et al, 2013; Albertsen et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(HM:"Glucose-6-phosphate dehydrogenase deficiency") association path(MESH:Thrombosis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

a(HM:"Glucose-6-phosphate dehydrogenase deficiency") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

This common X-linked inherited disorder, characterized by severe intravascular and extravascular haemolysis, is classically triggered by fava bean ingestion or pro-oxidant medications. It causes haemolysis in susceptible individuals and an association with thrombosis was described in multiple case reports (Jewett, 1976; Thompson et al, 2013; Albertsen et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.