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  3. p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))

p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00053
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

In-Edges 3

p(HBP:HBP00053) hasVariant p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) View Subject | View Object

Appears in Networks:

p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

The two pseudophosphorylated tau proteins (hTau40 AT8/AT100/PHF-1 and hTau40 4xKXGE) displayed significantly decreased lysosomal uptake when compared to hTau40 WT Tau (Fig. 7a,b) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) View Subject | View Object

This effect was more pronounced in the case of hTau40 4xKXGE, whose uptake and degradation by LE was completely abolished (Fig. 7d,e), suggesting that phosphorylation in the microtubule- binding domain diminishes its degradation by e-MI PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
Low
MeSH
Brain

Out-Edges 2

p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

The two pseudophosphorylated tau proteins (hTau40 AT8/AT100/PHF-1 and hTau40 4xKXGE) displayed significantly decreased lysosomal uptake when compared to hTau40 WT Tau (Fig. 7a,b) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) View Subject | View Object

This effect was more pronounced in the case of hTau40 4xKXGE, whose uptake and degradation by LE was completely abolished (Fig. 7d,e), suggesting that phosphorylation in the microtubule- binding domain diminishes its degradation by e-MI PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
Low
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.