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p(HGNC:MAPT, frag("258_360"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 3

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, frag("258_360")) View Subject | View Object

Appears in Networks:

p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) View Subject | View Object

In a cellular model of tauopathy, cells expressing the ΔK280 repeat-domain-mutant tau show tau aggregation that depends on the stepwise proteolysis of the N‑terminal domain by a thrombin-like protease and of the C‑terminal domain by cathepsin L, generating a fragment (F3) that leads to robust aggregation in cell and animal models PubMed:26631930

Appears in Networks:
Annotations
MeSH
Tauopathies

p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) View Subject | View Object

In a cellular model of tauopathy, cells expressing the ΔK280 repeat-domain-mutant tau show tau aggregation that depends on the stepwise proteolysis of the N‑terminal domain by a thrombin-like protease and of the C‑terminal domain by cathepsin L, generating a fragment (F3) that leads to robust aggregation in cell and animal models PubMed:26631930

Appears in Networks:
Annotations
MeSH
Tauopathies

Out-Edges 1

p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates") View Subject | View Object

In a cellular model of tauopathy, cells expressing the ΔK280 repeat-domain-mutant tau show tau aggregation that depends on the stepwise proteolysis of the N‑terminal domain by a thrombin-like protease and of the C‑terminal domain by cathepsin L, generating a fragment (F3) that leads to robust aggregation in cell and animal models PubMed:26631930

Appears in Networks:
Annotations
MeSH
Tauopathies

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.