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p(HBP:C99)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
C99
Namespace
HBP
Namespace Version
20190310
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/6e71f2b59daa002349a1e3eeae64412ce175745a/export/hbp-names.belns

Appears in Networks 2

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 3

p(HGNC:RELA) increases p(HBP:C99) View Subject | View Object

p65 expression significantly increased the amount of C99 in 20E2 cells by 152.29¡6.03% in the presence of NF-kB p65 relative to controls (p<0.001) (Fig. 5h, i). PubMed:21329555

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293

complex(GO:"NF-kappaB complex") regulates p(HBP:C99) View Subject | View Object

Recent studies have unveiled a novel role of NF-κB in the regulation of the γ-secretase activity mediated processing of the C99 (CTFβ) fragment PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"gamma-secretase complex") regulates p(HBP:C99) View Subject | View Object

Recent studies have unveiled a novel role of NF-κB in the regulation of the γ-secretase activity mediated processing of the C99 (CTFβ) fragment PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.