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albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

In-Edges 1

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) View Subject | View Object

Regarding the ascending afferent excitatory pain pathway, in which nicotinic antagonists are anticipated to have analgesic effects, a newly described subtype of nAChR, α9α10, seems to be expressed on dorsal root ganglia (in addition to the inner ear) and constitutes an in vitro target for new α-conotoxins, such as vc1.1, RgiA, or it14a237–241. PubMed:19721446

Out-Edges 6

a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) View Subject | View Object

Not unlike snake toxins, conotoxins can disrupt multiple components of neurotransmission including voltage-gated Na+ and K+ channels in addition to nAChRs (132, 351). PubMed:19126755

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a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) View Subject | View Object

Not unlike snake toxins, conotoxins can disrupt multiple components of neurotransmission including voltage-gated Na+ and K+ channels in addition to nAChRs (132, 351). PubMed:19126755

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Text Location
Review

a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels")) View Subject | View Object

Not unlike snake toxins, conotoxins can disrupt multiple components of neurotransmission including voltage-gated Na+ and K+ channels in addition to nAChRs (132, 351). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) View Subject | View Object

Regarding the ascending afferent excitatory pain pathway, in which nicotinic antagonists are anticipated to have analgesic effects, a newly described subtype of nAChR, α9α10, seems to be expressed on dorsal root ganglia (in addition to the inner ear) and constitutes an in vitro target for new α-conotoxins, such as vc1.1, RgiA, or it14a237–241. PubMed:19721446

a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) View Subject | View Object

In vivo, these α-conotoxins display potent alleviation of allopathic pain239,242,243 (and additionally reveal an endogeneous ACh activation of lymphocytes through α9α10 nAChRs, which are inhibited by these α-conotoxins). PubMed:19721446

a(MESH:Conotoxins) decreases path(MESH:Pain) View Subject | View Object

In vivo, these α-conotoxins display potent alleviation of allopathic pain239,242,243 (and additionally reveal an endogeneous ACh activation of lymphocytes through α9α10 nAChRs, which are inhibited by these α-conotoxins). PubMed:19721446

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