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p(HGNC:APP, pmod(HBP:polysumoylation))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
APP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 1

p(HGNC:APP) hasVariant p(HGNC:APP, pmod(HBP:polysumoylation)) View Subject | View Object

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Out-Edges 1

p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Increased protein sumoylation resulting from overexpression of SUMO-3 reduces Abeta production and reducing endogenous protein sumoylation with dominant-negative SUMO-3 mutants increases Abeta production. Mutant SUMO-3, K11R, which can only be monomerically conjugated to target proteins, has an opposite effect on Abeta generation to that by SUMO-3, which can form polymeric chains on target proteins. Polysumoylation reduces whereas monosumoylation or undersumoylation enhances Abeta generation. PubMed:12506199

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.