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composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1))

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Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 0

Out-Edges 4

composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) hasComponent p(HGNC:APP) View Subject | View Object

Appears in Networks:

composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) hasComponent p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) hasComponent p(HBP:"gamma-secretase") View Subject | View Object

Appears in Networks:

composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) View Subject | View Object

The accumulation of plaques consisting of Abeta is one of the histopathological hallmarks of AD. Abeta is the product of serial cleavage of the amyloid precursor protein (APP) first by beta and then by gamma secretases to yield Abeta peptides of varying lengths, predominantly the 37-, 40-, and 42- residue forms. PubMed:19293145

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.