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a(HM:schistocytosis)

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Entity

Name
schistocytosis
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:Thrombin) positiveCorrelation a(HM:schistocytosis) View Subject | View Object

However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

a(CHEBI:argatroban) decreases a(HM:schistocytosis) View Subject | View Object

Recently, using a rat model of lipopolysaccharide (LPS)-induced systemic inflammation, our own collaboration could show that argatroban (a specific direct thrombin inhibitor and consequently an inhibitor of coagulation) abolishes DIC, schistocyte formation, and hemolysis. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

a(CHEBI:eptifibatide) causesNoChange a(HM:schistocytosis) View Subject | View Object

Interestingly, inhibition of coagulation is capable of diminishing DIC and hemolysis but not antiplatelet therapy—treatment with eptifibatide (an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class) failed to reduce LPS-induced DIC, schistocyte formation, and hemolysis. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

Out-Edges 1

a(HM:schistocytosis) positiveCorrelation a(CHEBI:Thrombin) View Subject | View Object

However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.