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p(HGNC:MAPT, pmod(OGlyco))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 2

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(OGlyco)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(OGlyco)) View Subject | View Object

In AD, the O‑GlcNAcylation of tau is reduced — an effect that might contribute to the hyperphosphorylation and aggregation of tau PubMed:26631930

Appears in Networks:

Out-Edges 4

p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

In contrast to N‑glycosylation, O‑GlcNAcylation (a type of O‑glycosylation) of tau may protect it against phosphorylation, as it occupies the Ser or Thr residue of Ser‑Pro or Thr-Pro motifs PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") View Subject | View Object

In addition, O‑GlcNAcylation of tau can suppress tau aggregation PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") View Subject | View Object

In AD, the O‑GlcNAcylation of tau is reduced — an effect that might contribute to the hyperphosphorylation and aggregation of tau PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

In AD, the O‑GlcNAcylation of tau is reduced — an effect that might contribute to the hyperphosphorylation and aggregation of tau PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.