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a(HBP:"Corticobasal Degeneration")

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Entity

Name
Corticobasal Degeneration
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

In-Edges 10

a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

Similarly, the soluble fraction from AD contained the greatest level of TOC1 reactivity, followed by CBD and then PiD had the lowest signal (Fig. 6D; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 16.57, p = 0.001) PubMed:27574109

Appears in Networks:

a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

TOC1 detected significantly more oligomeric tau in AD compared to CBD and PiD and more in CBD compared to PiD (Fig. 6G; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 35.32, p < 0.0001) PubMed:27574109

Appears in Networks:

a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

Appears in Networks:

composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

TNT1 detected significantly more PAD exposed tau in AD compared to PiD, and more in CBD when compared to PiD, but AD and CBD were not different (Fig. 6F; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 12.07, p = 0.0028) PubMed:27574109

Appears in Networks:

p(HGNC:MAPT) association a(HBP:"Corticobasal Degeneration") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

Total tau levels in the soluble fractions were similar for AD, CBD and PiD, as indicated by the Tau5 sandwich ELISA (Fig. 6B; one-way ANOVA, F(2,9) = 3.283, p = 0.085) PubMed:27574109

Appears in Networks:

p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

Total tau levels in the insoluble fractions, as detected by Tau5, were highest in AD, followed by CBD and PiD contained the least (Fig. 6E; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 25.93, p = 0.0002) PubMed:27574109

Appears in Networks:

Out-Edges 10

a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") View Subject | View Object

Similarly, the soluble fraction from AD contained the greatest level of TOC1 reactivity, followed by CBD and then PiD had the lowest signal (Fig. 6D; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 16.57, p = 0.001) PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") View Subject | View Object

TOC1 detected significantly more oligomeric tau in AD compared to CBD and PiD and more in CBD compared to PiD (Fig. 6G; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 35.32, p < 0.0001) PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) View Subject | View Object

Total tau levels in the soluble fractions were similar for AD, CBD and PiD, as indicated by the Tau5 sandwich ELISA (Fig. 6B; one-way ANOVA, F(2,9) = 3.283, p = 0.085) PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) View Subject | View Object

Total tau levels in the insoluble fractions, as detected by Tau5, were highest in AD, followed by CBD and PiD contained the least (Fig. 6E; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 25.93, p = 0.0002) PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) View Subject | View Object

TNT1 detected significantly more PAD exposed tau in AD compared to PiD, and more in CBD when compared to PiD, but AD and CBD were not different (Fig. 6F; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 12.07, p = 0.0028) PubMed:27574109

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.