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a(CHEBI:hydroperoxide)

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Entity

Name
hydroperoxide
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

a(CHEBI:heme) increases a(CHEBI:hydroperoxide) View Subject | View Object

Once intercalated into cellular plasma membranes heme amplifies cellular susceptibility to oxidative-mediated injury by oxidants such as H2O2 or those derived from activated inflammatory cells (Balla et al., 1991a,b, 1993). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

bp(MESH:"Erythrocyte Deformability") negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(MGI:Prdx2) negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(MGI:Prdx2) negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(PFAM:GSHPx) negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

rxn(reactants(a(CHEBI:hydroperoxide)), products(a(CHEBI:hydroperoxyl), a(MESH:"alkoxyl radical"))) hasReactant a(CHEBI:hydroperoxide) View Subject | View Object

Appears in Networks:

Out-Edges 4

a(CHEBI:hydroperoxide) negativeCorrelation p(PFAM:GSHPx) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(CHEBI:hydroperoxide) negativeCorrelation p(MGI:Prdx2) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(CHEBI:hydroperoxide) negativeCorrelation p(MGI:Prdx2) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(CHEBI:hydroperoxide) negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.