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PubMed: 17954934

Title
BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.
Journal
The Journal of biological chemistry
Volume
282
Issue
None
Pages
37276-84
Date
2007-12-21
Authors
Tsvetkov P | Ginzburg I | Elliott E

Evidence 9bed3aa6b2
JSON

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein.

act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

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