p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1)

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PubMed:17954934

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein.

Related Edges 7

• act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT))
• act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1)
• p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1)
• p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT)
• p(HGNC:BAG1) decreases deg(p(HGNC:MAPT))
• p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex"))
• p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph))

Experimental Factor Ontology (EFO)

HEK293

MeSH

Hippocampus

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