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PubMed: 16820021

Title
The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats.
Journal
The European journal of neuroscience
Volume
23
Issue
None
Pages
3319-27
Date
2006-06-01
Authors
Lawrence AJ | Lodge DJ | Card K | Djouma E

Evidence 1cf05f1946
JSON

Autoradiographic detection of dopamine D1 receptors by [125I]- SCH 23982 was fully displaceable by the agonist SKF-77434.

a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") View Subject | View Object

Appears in Networks:

Evidence 33f41768ff
JSON

Overall, no changes were observed in dopamine D1 receptor binding in the brain regions examined following social isolation and ⁄ or antalarmin treatment under these conditions

a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) View Subject | View Object

Appears in Networks:

Evidence d294f59a21
JSON

antalarmin increased dopamine D2 ⁄ 3 binding in the CPu (+7%, P < 0.001; Fig. 3C) and olfactory tubercle (OT; +15%, P 1⁄4 0.006; Fig. 3D) of group-housed rats.

a(MESH:antalarmin) increases p(RGD:Drd2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neostriatum
MeSH
Olfactory Tubercle

a(MESH:antalarmin) increases p(RGD:Drd3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neostriatum
MeSH
Olfactory Tubercle

Evidence 1cd530eae7
JSON

Antalar- min treatment reversed this effect and returned dopamine D2 ⁄ 3 receptor density levels back to those of the vehicle-treated GH rats.

a(MESH:antalarmin) decreases p(RGD:Drd2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

a(MESH:antalarmin) decreases p(RGD:Drd3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

Evidence d8c4f9f1b6
JSON

Furthermore a significant interaction was found between housing and treatment in both the central nucleus of the amygdala (CeA; F1,139 1⁄4 11.560, P < 0.001; Fig. 3F) and basolateral amygdala (BLA; F1,137 1⁄4 7.616, P 1⁄4 0.007; Fig. 3E).Thus, isolation caused an up-regulation in dopamine D2 ⁄ 3 receptors in these regions, an effect that was reversed by antalarmin treatment (but only reached statistical significance in the CeA).

a(MESH:antalarmin) decreases path(HBP:"isolation rearing") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

Evidence 2a7478dd0f
JSON

Treatment with antalarmin had no impact upon the isolation-induced alterations of BDNF expression.

a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

Evidence 4a9ada78d3
JSON

As was the case with BDNF expression, treatment with antalarmin had no impact upon the isolation-induced alterations in TrkB expression.

a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Dentate Gyrus
MeSH
Hippocampus

Evidence 9b03e4132d
JSON

Interestingly however, antalarmin treatment of GH rats caused a down-regulation of TrkB mRNA in the LC ()15%, P 1⁄4 0.012) and Pir ()26%, P 1⁄4 0.013) whilst increases were observed in the hippocampus (CA1–3; +36%, P 1⁄4 0.042) and RSc (+53%, P < 0.001).

a(MESH:antalarmin) decreases r(RGD:Ntrk2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Piriform Cortex

a(MESH:antalarmin) increases r(RGD:Ntrk2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

Evidence fc47d4b2cd
JSON

Isolation rearing caused an up-regulation of dopamine D2 ⁄ 3 receptors in both the core (+20%; F1,144 1⁄4 31.176, P < 0.001; Fig. 3A) and shell (+25%; F1,148 1⁄4 35.233, P < 0.001; Fig. 3B) of the NAcc.

path(HBP:"isolation rearing") increases p(RGD:Drd2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

Evidence 57ea57087e
JSON

A significant decrease in BDNF mRNA expression resulting from ISO was found in the BLA ()25%; F1,102 1⁄4 77.937, P < 0.001), nucleus of the horizontal limb of the diagonal band (HB )75%; F1,67 1⁄4 259.106, P < 0.001) and dentate gyrus (DG )85%; F1,101 1⁄4 984.958,

path(HBP:"isolation rearing") decreases r(RGD:Bdnf) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

Evidence b8fa1ca2fa
JSON

whilst isolation increased BDNF mRNA expression in the retrosplenial cortex

path(HBP:"isolation rearing") increases r(RGD:Bdnf) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

Evidence b981725f8f
JSON

ISO resulted in a decrease in TrkB mRNA expression in the cingulate cortex (Cg1–3; F1,124 1⁄4 7.582, P 1⁄4 0.014) and piriform cortex (Pir; F1,119 1⁄4 3.869

path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Gyrus Cinguli
MeSH
Piriform Cortex

Evidence eb8155d64c
JSON

whereas an increase was observed in isolates compared to GH in the hippocampus (+38%; F1,59 1⁄4 14.131, P < 0.001), DG (+32%; F1,56 1⁄4 8.398, P 1⁄4 0.005) and RSc (+32%; F1,56 1⁄4 6.830, P 1⁄4 0.011).

path(HBP:"isolation rearing") increases r(RGD:Ntrk2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Dentate Gyrus
MeSH
Hippocampus

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