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PubMed: 24686445

Title
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Journal
Nature communications
Volume
5
Issue
None
Pages
3527
Date
2014-04-01
Authors
Puttagunta R | Di Giovanni S | Boutillier AL | Bradke F | Gaub P | Hervera A | Joshi Y | Laskowski CJ | Lindner R | Nguyen T | Rathore KI | Schmandke A | Sória MG | Tedeschi A

Evidence 5aae6ded33
JSON

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury.

a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF) View Subject | View Object

Appears in Networks:
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Uberon
dorsal root ganglion

act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43) View Subject | View Object

Appears in Networks:
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Uberon
dorsal root ganglion

p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

p(HGNC:NGF) increases act(p(HGNC:KAT2B)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

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