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p(FPLX:ERK, pmod(Ph))

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Entity

Name
ERK
Namespace
FPLX
Namespace Version
20180917
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Appears in Networks 3

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

In-Edges 9

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

ERK phosphorylation in MAPT mutant neurons was blocked by treatment with PD98059, a specific inhibitor of MEK-mediated activation of ERK (Li et al., 2001) (Figures 4B and 4C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

The level of phosphorylated ERK (p-ERK) was significantly increased in tau-A152T neurons and to a lesser extent in MAPT IVS10+16 patient neurons (Figure 4A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(FPLX:ERK) hasVariant p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) View Subject | View Object

ERK phosphorylation is also not affected by A152T mutation in 3R tau (Figure S4D) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
Medium
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Correspondingly, the level of p-ERK was also elevated in HEK293 cells expressing tau-A152T (Figure 4E) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
Medium
MeSH
Frontotemporal Dementia

act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) View Subject | View Object

We found the level and activity of secreted MMP-9 to correlate well with the extent of ERK phosphorylation (Figure S4A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) View Subject | View Object

We found the level and activity of secreted MMP-9 to correlate well with the extent of ERK phosphorylation (Figure S4A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. PubMed:24686445

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Macranthoin G inhibited the NF-B pathway and activated the phosphorylation of IB, p38 and ERK, and thus, min-imized cell damage [131]. PubMed:29179999

Appears in Networks:

Out-Edges 3

p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) View Subject | View Object

We found the level and activity of secreted MMP-9 to correlate well with the extent of ERK phosphorylation (Figure S4A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) View Subject | View Object

We found the level and activity of secreted MMP-9 to correlate well with the extent of ERK phosphorylation (Figure S4A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) View Subject | View Object

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. PubMed:24686445

Appears in Networks:
Annotations
Uberon
dorsal root ganglion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.