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p(HBP:HBP00044, var("p.Ala152Thr"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00044
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

In-Edges 1

p(HBP:HBP00044) hasVariant p(HBP:HBP00044, var("p.Ala152Thr")) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) View Subject | View Object

Interestingly, the level and activity of secreted MMP-9 in HEK293 cells expressing WT 3R tau and 3R tau-A152T are similar (Figures S4B and S4C) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) View Subject | View Object

Interestingly, the level and activity of secreted MMP-9 in HEK293 cells expressing WT 3R tau and 3R tau-A152T are similar (Figures S4B and S4C) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) View Subject | View Object

ERK phosphorylation is also not affected by A152T mutation in 3R tau (Figure S4D) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
Medium
MeSH
Frontotemporal Dementia

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.