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a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
2-(2-amino-3-methoxyphenyl)chromen-4-one
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 7

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

ERK phosphorylation in MAPT mutant neurons was blocked by treatment with PD98059, a specific inhibitor of MEK-mediated activation of ERK (Li et al., 2001) (Figures 4B and 4C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) View Subject | View Object

Correspondingly, the level and activity of secreted MMP-9 was greatly suppressed in both tau-A152T and MAPT IVS10+16 patient neurons (Figures 4B and 4C), suggesting that MMP-9 expression is regulated by the ERK signaling pathway in cortical neurons PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) View Subject | View Object

Correspondingly, the level and activity of secreted MMP-9 was greatly suppressed in both tau-A152T and MAPT IVS10+16 patient neurons (Figures 4B and 4C), suggesting that MMP-9 expression is regulated by the ERK signaling pathway in cortical neurons PubMed:27594586

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) View Subject | View Object

Interestingly, the level and activity of MMP-2 was not affected after the PD98059 treatment in tau-A152T neurons (Figure 4B) and MAPT IVS10+16 neurons (Figure 4C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) View Subject | View Object

Interestingly, the level and activity of MMP-2 was not affected after the PD98059 treatment in tau-A152T neurons (Figure 4B) and MAPT IVS10+16 neurons (Figure 4C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell proliferation") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell migration") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.