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bp(GO:"cell migration")

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Entity

Name
cell migration
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell migration") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:Trolox) decreases bp(GO:"cell migration") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

Appears in Networks:
Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:dibenziodolium) decreases bp(GO:"cell migration") View Subject | View Object

Moreover, DPI strongly inhibited heme-induced VSMC migration (Fig. 2B) and blunted the proliferative capability of heme-treated VSMC that reached levels below the controls. (Fig. 2C), indicating that heme effects on VSMC migration and proliferation are modulated by NADPHox. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

p(RGD:Mapk1) positiveCorrelation bp(GO:"cell migration") View Subject | View Object

Among the redox-sensitive molecules, ERK-2, a member of MAPK family, is of crucial importance to VSMC proliferation and migration [21]. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

Out-Edges 1

bp(GO:"cell migration") positiveCorrelation p(RGD:Mapk1) View Subject | View Object

Among the redox-sensitive molecules, ERK-2, a member of MAPK family, is of crucial importance to VSMC proliferation and migration [21]. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.