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Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

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a(CHEBI:Trolox) decreases bp(GO:"cell proliferation") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

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Muscle, Smooth, Vascular
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a(CHEBI:Trolox) decreases bp(GO:"cell migration") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

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Muscle, Smooth, Vascular
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a(CHEBI:Trolox) decreases bp(MESH:"Lipid Peroxidation") View Subject | View Object

In contrast, at an equal antioxidant concentration, Trolox completely blocked heme-triggered lipid peroxidation (measured as production of thiobarbituric acid reactive substances (TBARS)) in soybean lecithin micelles (Figure 7g). PubMed:25301065

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.