p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK))

View Subject View Object

PubMed:24686445

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury.

Related Edges 9

• a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF)
• act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B))
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43)
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL)
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF)
• act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK))
• act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9))
• p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph))
• p(HGNC:NGF) increases act(p(HGNC:KAT2B))

Uberon

dorsal root ganglion

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---