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p(HBP:HBP00045, var("p.Ala152Thr"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00045
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

In-Edges 1

p(HBP:HBP00045) hasVariant p(HBP:HBP00045, var("p.Ala152Thr")) View Subject | View Object

Appears in Networks:

Out-Edges 9

p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) View Subject | View Object

However, the secreted MMP-9 level and activity in conditioned medium was significantly higher in cultures of cells expressing tau-A152T than WT tau (Figure 4E) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) View Subject | View Object

However, the secreted MMP-9 level and activity in conditioned medium was significantly higher in cultures of cells expressing tau-A152T than WT tau (Figure 4E) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) View Subject | View Object

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) View Subject | View Object

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) View Subject | View Object

The MMP-9 mRNA level was also higher in cells expressing tau-A152T (Figure 4F) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) View Subject | View Object

Correspondingly, the level of p-ERK was also elevated in HEK293 cells expressing tau-A152T (Figure 4E) PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
Medium
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") View Subject | View Object

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) View Subject | View Object

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) View Subject | View Object

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway PubMed:27594586

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Confidence
High
MeSH
Frontotemporal Dementia

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.