p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2))

View Subject View Object

PubMed:27594586

Taken together, these findings strongly suggest that 4R tau-A152T activates the ERK pathway more strongly, which in turn increases the level and activity of secreted MMP-9. 4R tau-A152T expression (Figures 4E and 4F) but not inhibition of ERK activity (Figures 4B and 4C) also increases the total activity of secreted MMP-2, suggesting that tau-A152T increases the level and activity of secreted MMP-2, likely through an ERK-independent pathway

Related Edges 4

• p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
• p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9))
• p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade")
• p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2))

Experimental Factor Ontology (EFO)

HEK293

Confidence

High

MeSH

Frontotemporal Dementia

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---