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PubMed: 25995053

Title
A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau.
Journal
Cerebral cortex (New York, N.Y. : 1991)
Volume
25
Issue
None
Pages
4559-71
Date
2015-11-01
Authors
Wu J | Wang S | Pei L | Lu Y | Bi L | Guo Y | Jin H | Li H | Pang P | Shang Y | Shu S | Tian Q | Tian T | Wei N | Xu M | Yan H | Yang X | Yao C | Zhu LQ

Evidence 1343cdcabb
JSON

Direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death. DAPK1 phosphorylates Tau protein at Ser262 (pS(262)) in cortical neurons of stroke mice.

p(MGI:Mapt) association p(MGI:Dapk1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Stroke

complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Stroke

p(MGI:Dapk1) association p(MGI:Mapt) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Stroke

p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Stroke

p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
MeSH
Stroke

p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
MeSH
Stroke

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