Furthermore, anatabine has been recently shown to inhibit nuclear factor-kB(NF-kB) activation and reduce neuroinflammation in a mouse model of Alzheimer disease (15).
Anatabine significantly decreased the severity of EAT induced with our standard induction protocol.
Anatabine treated mice developed lower levels of thyroglobulin antibodies than controls on d 14 (P 0.029) and d 21 (P 0.045) (Fig. 2A), suggesting that anatabine atten- uates the thyroid-specific autoimmune response in- duced by thyroglobulin immunization.
Anatabine suppressed the EAT-mediated increase of IL-1 receptor type 2 (IL-1R2, Figure 3A) and IL-18 (Fig. 3B), restoring their expression to levels similar to those seen in normal unimmunized thyroids.
Anatabine suppressed in a dose- dependent manner the increase of iNOS and COX2 in- duced by interferon-g (Fig.4),confirming in vitro its antiinflammatory properties. The effect seen with inter- feron-g was also seen when macrophages were stimulated with lipopolysaccharide (Supplemental Fig. 1).
Smokers in the Third National Health and Nutri- tion Examination Survey were found to have lower prev- alence of thyroperoxidase and/or thyroglobulin antibod- ies than nonsmokers (1).
Tobacco smoking has numerous detrimental effects on human health, but it has also been associated with a few apparent salutary actions, including the amelioration of autoimmune (Hashimoto) thyroiditis and ulcerative colitis.
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.