1. Catalog
  2. Citations
  3. PubMed:21787755

PubMed: 21787755

Title
Naturally-expressed nicotinic acetylcholine receptor subtypes.
Journal
Biochemical pharmacology
Volume
82
Issue
None
Pages
800-7
Date
2011-10-15
Authors
Lukas RJ | Wu J

Evidence 54ea7e2e95
JSON

In terms of functional effects, nicotine acts acutely much in the way that ACh does, causing opening of nAChR channels.

a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) View Subject | View Object

Appears in Networks:

a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) View Subject | View Object

Appears in Networks:

Evidence e5ee135575
JSON

There is an emerging consensus that nAChR a6 subunit mRNA and proteins are distributed in brain regions thought to be involved in reward and drug reinforcement, in theory being involved in DA release [135].

sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:CHRNA6) association path(MESH:Reward) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Reward) association r(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Reward) association p(HGNC:CHRNA6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

r(HGNC:CHRNA6) association path(MESH:Reward) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

Evidence fbee33a219
JSON

Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release.

a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

Evidence 39964b4596
JSON

b4 subunit mRNA colocalizes with a4 subunit mRNA in many brain regions [37,38] that could be involved in complex behaviors including nicotine dependence.

r(HGNC:CHRNB4) association r(HGNC:CHRNA4) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

r(HGNC:CHRNA4) association r(HGNC:CHRNB4) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

Evidence 3537e3110d
JSON

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control

a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

Evidence 826dc47cfb
JSON

Recently, we reported a novel discovery that functional a6*-nAChRs are located on GABAergic presynaptic boutons associated with VTA DAergic neurons, where these a6*- nAChRs mediate nicotinic modulation of GABA release onto those DAergic neurons [122].

a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

Evidence 6e9e656f05
JSON

This makes the hypothesis particularly intriguing that a6*-nAChRs play roles in nicotine dependence.

a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

Appears in Networks:

Evidence ea808654f7
JSON

There is good evidence that a6*-nAChRs, in particular, modulate neurotransmitter release in multiple brain regions.

a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain

Evidence c3f277cf68
JSON

Subsequently, renewed searches for functions of natural Bgt-binding nAChRs uncovered short-lived, nicotine-gated, toxin-sensitive, inward currents and/ or elevations of intracellular Ca2+ in chick autonomic neurons [84], in human ganglionic neuron-like clonal cells [85], or in rat CNS neurons [16,40–44,86–91].

a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
neuron

Evidence bbcb9f8975
JSON

By virtue of their unique subcellular localizations, channel kinetics and Ca2+ permeability, a7-nAChRs appear to have novel functional roles in addition to (i.e., distinct from) the mediation of classical excitatory neurotransmission.

a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") View Subject | View Object

Appears in Networks:

Evidence a672e60eeb
JSON

For example, Bgt-sensitive a7-nAChRs have been implicated in processes such as vicinal control of neurotransmitter release [7,14], development and maintenance of neurites and synapses [18–20], long-term potentiation [95,96], seizures [97], and neuronal viability/death [21–24]. These intriguing findings underscore the need for further characterization of functional a7-nAChRs.

a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") View Subject | View Object

Appears in Networks:

a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") View Subject | View Object

Appears in Networks:

a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") View Subject | View Object

Appears in Networks:

a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:

a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) View Subject | View Object

Appears in Networks:

bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

Appears in Networks:

Evidence be8148b38d
JSON

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129].

a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Appears in Networks:

a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Appears in Networks:

a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Appears in Networks:

a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Appears in Networks:

a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Appears in Networks:

a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Appears in Networks:

Evidence 7c0edf2bba
JSON

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33].

a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Appears in Networks:

a(HBP:AβOs) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

a(HBP:AβOs) association path(MESH:Epilepsy) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") association a(HBP:AβOs) View Subject | View Object

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) View Subject | View Object

Appears in Networks:

path(MESH:Epilepsy) association a(HBP:AβOs) View Subject | View Object

Appears in Networks:

Evidence 763df70b50
JSON

Initially, a-CtxMII was thought to be highly selective for a3b2*-nAChRs [124] and became a useful tool for investigating receptor structure [125].

a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Appears in Networks:

Evidence 2ec3c2afb1
JSON

Moreover, some nAChRs have been implicated in processes such as the structuring and maintenance of neurites and synapses [18–20] and even in modulation of neuronal viability/death [21–24].

p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.