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Appears in Networks 3

In-Edges 3

path(MESH:"Alzheimer Disease") association a(HBP:AβOs) View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

path(MESH:Epilepsy) association a(HBP:AβOs) View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

Out-Edges 13

a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

a(HBP:AβOs) association path(MESH:"Alzheimer Disease") View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

a(HBP:AβOs) association path(MESH:Epilepsy) View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

a(HBP:AβOs) decreases act(a(GO:synapse)) View Subject | View Object

Among the various molecular species of Abeta present in the brain, soluble oligomeric forms of Abeta are arguably the most plausible candidates to impair synaptic function (reviewed in Walsh and Selkoe 2004). PubMed:22908190

a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Soluble Ab oligomers inhibit hippocampal long-term potentiation and alter memory and learning performance PubMed:22908190

a(HBP:AβOs) decreases bp(GO:learning) View Subject | View Object

Soluble Ab oligomers inhibit hippocampal long-term potentiation and alter memory and learning performance PubMed:22908190

a(HBP:AβOs) decreases bp(GO:memory) View Subject | View Object

Soluble Ab oligomers inhibit hippocampal long-term potentiation and alter memory and learning performance PubMed:22908190

a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") View Subject | View Object

They also facilitate long-term depression by, among other effects, disrupting synaptic glutamate uptake (Li et al. 2009). PubMed:22908190

a(HBP:AβOs) decreases bp(GO:"L-glutamate import") View Subject | View Object

They also facilitate long-term depression by, among other effects, disrupting synaptic glutamate uptake (Li et al. 2009). PubMed:22908190

a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Recently, it has been shown that soluble Ab oligomers isolated from AD cortex can induce tau hyperphosphorylation at AD-relevant epitopes and subsequent neuritic degeneration (Jin et al. 2011). PubMed:22908190

a(HBP:AβOs) increases deg(a(MESH:Neurites)) View Subject | View Object

Recently, it has been shown that soluble Ab oligomers isolated from AD cortex can induce tau hyperphosphorylation at AD-relevant epitopes and subsequent neuritic degeneration (Jin et al. 2011). PubMed:22908190

a(HBP:AβOs) decreases act(complex(GO:"proteasome complex")) View Subject | View Object

Moreover, soluble Ab oligomers themselves can inhibit proteasomal activity (Tseng et al. 2008). PubMed:22908190

a(HBP:AβOs) decreases a(MESH:"Dendritic Spines") View Subject | View Object

For comparison, in the case of Ab oligomers, only higher concentrations (w1 mM) cause an appreciable spine reduction of w30% (Fig. 4C, bar 3) (Zempel et al., 2010 [30]). PubMed:28528849

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.