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bp(GO:"long-term synaptic depression")

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Entity

Name
long-term synaptic depression
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 3

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Tau in physiology and pathology v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 5

a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") View Subject | View Object

They also facilitate long-term depression by, among other effects, disrupting synaptic glutamate uptake (Li et al. 2009). PubMed:22908190

Appears in Networks:

act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") View Subject | View Object

Pathological Rab5 activation driving endocytic dysfunction in AD may negatively impact longterm potentiation (LTP) and long-term depression (LTD) aspects of synaptic plasticity closely associated with learning and memory (Kessels et al. 2009) PubMed:22908190

Appears in Networks:

p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") View Subject | View Object

A selective deficit in LTD but not in long-term potentiation (LTP) was observed in the CA1 region of the hippocampus in tau-knockout mice in vivo and ex vivo PubMed:26631930

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal

p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") View Subject | View Object

In addition, as tau is involved in multiple novel functions, including iron transport, neurogenesis, LTD and neuronal DNA protection (as discussed above), the loss of function of tau may also lead to neurodegeneration via impairment of these processes. PubMed:26631930

Appears in Networks:

p(HGNC:REL) increases bp(GO:"long-term synaptic depression") View Subject | View Object

c-Rel null mice exhibit deficits in hippocampal long term depression (LTD), despite the lack of presence of c-Rel at the synapses in wild-type mic PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

Out-Edges 3

bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) View Subject | View Object

Pathological Rab5 activation driving endocytic dysfunction in AD may negatively impact longterm potentiation (LTP) and long-term depression (LTD) aspects of synaptic plasticity closely associated with learning and memory (Kessels et al. 2009) PubMed:22908190

Appears in Networks:

bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) View Subject | View Object

The expression of p65 and p50 is induced in response to long-term changes in synaptic strength and transmission such as LTP [39] and LTD PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) View Subject | View Object

The expression of p65 and p50 is induced in response to long-term changes in synaptic strength and transmission such as LTP [39] and LTD PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.