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PubMed: 30248094

Title
Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney.
Journal
PLoS genetics
Volume
14
Issue
None
Pages
e1007665
Date
2018-09-01
Authors
Chambers I | Hamza I | Krause M | Phillips J | Yun S | Zhang J

Evidence c0dbfb49e5
JSON

It has been reported that an increase in extracellular heme activates NLRP3 expression, triggering inflammasome activation [28].

a(CHEBI:heme) positiveCorrelation p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

p(HGNC:NLRP3) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

p(HGNC:NLRP3) increases act(a(MESH:Inflammasomes)) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

Evidence f84741c54c
JSON

Upon degradation of RBCs in the erythrophagosome, heme is imported into the cytoplasm for degradation by the heme-degrading enzyme heme oxygenase-1 (HMOX1) [7].

a(CHEBI:heme) positiveCorrelation deg(a(MESH:Erythrocytes)) View Subject | View Object

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Introduction

deg(a(MESH:Erythrocytes)) positiveCorrelation a(CHEBI:heme) View Subject | View Object

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Text Location
Introduction

p(HGNC:HMOX1) increases deg(a(CHEBI:heme)) View Subject | View Object

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MeSH
Cytoplasm
Text Location
Introduction

Evidence f1bd454d87
JSON

Expression of zebrafish hrg1a and hrg1b rescued growth of hem1Δ yeast at heme concentrations as low as 0.25 μM, comparable to the established heme transporters CeHRG-4 and CeHRG-1, demonstrating that Hrg1a and Hrg1b are heme transporters (Fig 1G) [10].

bp(GO:"heme transport") positiveCorrelation p(HGNC:SLC48A1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Results

p(HGNC:SLC48A1) positiveCorrelation bp(GO:"heme transport") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Results

Evidence a722943686
JSON

We show that the zebrafish kidney is the primary organ for heme-iron recycling during EP and that zebrafish Hrg1a and Hrg1b are heme transporters that are expressed and upregulated in kidney macrophages after PHZ-induced hemolysis.

bp(GO:"heme transport") positiveCorrelation p(HGNC:SLC48A1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

p(HGNC:SLC48A1) positiveCorrelation bp(GO:"heme transport") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

p(HGNC:SLC48A1) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation p(HGNC:SLC48A1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

Evidence fc0f4f7693
JSON

When RBCs become senescent or the number of damaged RBCs increases in the circulation, macrophages from the reticuloendothelial system (RES, spleen and liver) contribute to RBC clearance and subsequently promote heme-iron recycling through erythrophagocytosis (EP).

bp(HM:"heme-iron recycling") positiveCorrelation bp(HM:erythrophagocytosis) View Subject | View Object

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Introduction

bp(HM:erythrophagocytosis) positiveCorrelation bp(HM:"heme-iron recycling") View Subject | View Object

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Introduction

Evidence a3b54103de
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HRG1 mRNA is upregulated during erythrophagocytosis (EP) in mouse bone marrow derived macrophages (BMDMs) and HRG1 protein is strongly expressed in macrophages of the reticuloendothelial system (RES) and specifically localizes to the phagolysosomal membranes [11].

bp(HM:erythrophagocytosis) positiveCorrelation r(MGI:Slc48a1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Introduction

bp(HM:erythrophagocytosis) positiveCorrelation p(MGI:Slc48a1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Introduction

p(MGI:Slc48a1) positiveCorrelation bp(HM:erythrophagocytosis) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Introduction

r(MGI:Slc48a1) positiveCorrelation bp(HM:erythrophagocytosis) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cytoplasm
Text Location
Introduction

Evidence f488612182
JSON

Our results show that hamp1 levels are significantly elevated in the presence of PHZ but is equivalent in both, WT and DKO fish (S6 Fig).

p(HGNC:HAMP) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation p(HGNC:HAMP) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney
Text Location
Results

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