1. Catalog
  2. Citations
  3. PubMed:17493042

PubMed: 17493042

Title
Structural principles of tau and the paired helical filaments of Alzheimer's disease.
Journal
Brain pathology (Zurich, Switzerland)
Volume
17
Issue
None
Pages
83-90
Date
2007-01-01
Authors
Biernat J | Mandelkow E | Mandelkow EM | von Bergen M

Evidence b46cbf4a15
JSON

Tau binds to microtubule through the C-terminal repeat domain and 4R bind more tightly than 3R, while phosphorylation, especially of the repeat domain tends to decrease binding.

a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

Evidence 8be7abfe46
JSON

A further potent detaching site is phosphoS214, which can be phosphorylated by PKA and other kinases of the AGC group (PKA/PKG/PKC group of protein kinases), and is up-regulated during mitosis (16, 63). Tau contains one or two cysteines in the repeat domain (C291 in R2, present in 4R isoforms, and C322 in R3), which can be engaged in intra- or intermolecular cross-linking affecting conformation, dimerization and aggregation (108).

bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

Evidence 2c2795cba6
JSON

Two hexapeptide motifs at the beginning of R2 and R3 promote paired helical filament (PHF) aggregation by inducing β-structure.

p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

Evidence f1a8401428
JSON

Tyrosine kinases target Y18 [fyn, (79)] and Y394 [abl, (31)].

p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

Evidence 4d4f43ecc7
JSON

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)].

p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.