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  3. a(HBP:"microtubule-binding region")

a(HBP:"microtubule-binding region")

Equivalencies: 3 | Classes: 0 | Children: 0 | Explore

Entity

Name
microtubule-binding region
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 3

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 19

p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") View Subject | View Object

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act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region") View Subject | View Object

For these studies, SH-SY5Y cells stably overexpressing tTG were used. tTG coimmunoprecipitated with tau, and elevating intracellular calcium levels with maitotoxin resulted in a 52 +/- 4% increase in the amount of tTG that coimmunoprecipitated with tau. The increase in association of tTG with tau after treatment with maitotoxin corresponded to a coimmunolocalization of tTG, tTG activity, and tau in the cells. Further, tau was modified by tTG in situ in response to maitotoxin treatment. In vitro polyaminated tau was significantly less susceptible to micro-calpain proteolysis; however, tTG-mediated polyamination of tau did not significantly alter the microtubule-binding capacity of tau. PubMed:10537045

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p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") View Subject | View Object

Apart from binding to MT, the repeat domains of tau also bind to tubulin deacetylase, histone deacetylase 6 (HDAC6) [68] and apolipoprotein E (apoE) more with the PubMed:26751493

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p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

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Out-Edges 11

a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) View Subject | View Object

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a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) View Subject | View Object

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a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Tau binds to microtubule through the C-terminal repeat domain and 4R bind more tightly than 3R, while phosphorylation, especially of the repeat domain tends to decrease binding. PubMed:17493042

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Annotations
Uberon
brain

a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") View Subject | View Object

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a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) View Subject | View Object

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a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) View Subject | View Object

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a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) View Subject | View Object

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a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) View Subject | View Object

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a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) View Subject | View Object

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a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) View Subject | View Object

For these studies, SH-SY5Y cells stably overexpressing tTG were used. tTG coimmunoprecipitated with tau, and elevating intracellular calcium levels with maitotoxin resulted in a 52 +/- 4% increase in the amount of tTG that coimmunoprecipitated with tau. The increase in association of tTG with tau after treatment with maitotoxin corresponded to a coimmunolocalization of tTG, tTG activity, and tau in the cells. Further, tau was modified by tTG in situ in response to maitotoxin treatment. In vitro polyaminated tau was significantly less susceptible to micro-calpain proteolysis; however, tTG-mediated polyamination of tau did not significantly alter the microtubule-binding capacity of tau. PubMed:10537045

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a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) View Subject | View Object

Apart from binding to MT, the repeat domains of tau also bind to tubulin deacetylase, histone deacetylase 6 (HDAC6) [68] and apolipoprotein E (apoE) more with the PubMed:26751493

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.