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complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))

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Components

Appears in Networks 1

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

In-Edges 6

a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Tau binds to microtubule through the C-terminal repeat domain and 4R bind more tightly than 3R, while phosphorylation, especially of the repeat domain tends to decrease binding. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

Tau binds to microtubule through the C-terminal repeat domain and 4R bind more tightly than 3R, while phosphorylation, especially of the repeat domain tends to decrease binding. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)]. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)]. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)]. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) View Subject | View Object

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)]. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

Out-Edges 2

complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) hasComponent p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) hasComponent p(HGNCGENEFAMILY:Tubulins) View Subject | View Object

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.