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p(HGNC:MAPT, pmod(Ac, Lys, 317))

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ac, Lys, 317)) View Subject | View Object

Appears in Networks:

act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) View Subject | View Object

Incubation with p300, not pCAF, led to tau acetylation, while both p300 and pCAF were active in transferring acetyl groups to histones as expected (Figure 1A). A few putative acetylated lysines were in the N- and C- terminal regions; 13 were in microtubule-binding domains (Figure 1B and Table-S1). Putative acetylated N-terminal lysines (e.g., lysines 163, 174, and 180) appeared to be acetylated in all MS analyses. Those in the microtubule-binding domains appeared to be acetylated in a subset of MS analyses, suggesting variable acetylation at these sites in vitro. PubMed:20869593

Appears in Networks:

Out-Edges 2

p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.