Title

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments.

Journal

FEBS letters

Volume

399

Issue

None

Pages

344-9

Date

1996-12-16

Authors

Kampers T | Friedhoff P | Biernat J | Mandelkow E | Mandelkow EM

As noticed earler, it is difficult to obtain PHFs from constructs containing domains outside the repeats or the second repeat, at least under conditions where assembly is driven by high ionic strength and high protein concentration [5,26]. This would suggest that some non-repeat domains of tau prevent PHF formation. The same tendency is observed here again, but low we find that the inhibition can be easily overcome by RNA in most cases. Since dimers are building blocks of PHFs, the extra repeat (no. 2) effectively acted as a PHF inhibitor [22]. However, this inhibition can be overcome by tRNA.

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