a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly")

PubMed:8985176

As noticed earler, it is difficult to obtain PHFs from constructs containing domains outside the repeats or the second repeat, at least under conditions where assembly is driven by high ionic strength and high protein concentration [5,26]. This would suggest that some non-repeat domains of tau prevent PHF formation. The same tendency is observed here again, but low we find that the inhibition can be easily overcome by RNA in most cases. Since dimers are building blocks of PHFs, the extra repeat (no. 2) effectively acted as a PHF inhibitor [22]. However, this inhibition can be overcome by tRNA.

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.