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a(CHEBI:"transfer RNA")

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Entity

Name
transfer RNA
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

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a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

As noticed earler, it is difficult to obtain PHFs from constructs containing domains outside the repeats or the second repeat, at least under conditions where assembly is driven by high ionic strength and high protein concentration [5,26]. This would suggest that some non-repeat domains of tau prevent PHF formation. The same tendency is observed here again, but low we find that the inhibition can be easily overcome by RNA in most cases. Since dimers are building blocks of PHFs, the extra repeat (no. 2) effectively acted as a PHF inhibitor [22]. However, this inhibition can be overcome by tRNA. PubMed:8985176

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.