r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease")

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PubMed:22299660

Decreased mRNA levels of PP2A C have been reported in the CA3 region of AD hippocampus by in situ RNA hybridisation [56]. Moreover, microarray RNA analysis carried out to compare the expression of more than 7,000 gene in the amygdala, cingulate cortex, striatum and cerebellum dis- closed down-regulation of the catalytic subunit PP2A C
in AD [57]. This has been further corroborated by quantitative TaqMan PCR showing reduced PP2A C
mRNA expression levels in the hippocampus, but not in the frontal cortex, in AD cases with disease progression Fig. (1).

Related Edges 3

• path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA)
• path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB)
• r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease")

MeSH

CA3 Region, Hippocampal

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