1. Catalog
  2. Nodes
  3. r(HGNC:PPP2CB)

r(HGNC:PPP2CB)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPP2CB
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

PP2A and Alzheimer Disease v1.0.0

In-Edges 2

path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) View Subject | View Object

Deficits in PP2A activity are in line with the reported down-regulation of PP2A catalytic C subunit at the gene (Loring et al.,2001), mRNA (Vogelsberg-Ragaglia et al.,2001) and protein (Sontag et al.,2004b) expression levels in AD. PubMed:24653673

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) View Subject | View Object

Decreased mRNA levels of PP2A C have been reported in the CA3 region of AD hippocampus by in situ RNA hybridisation [56]. Moreover, microarray RNA analysis carried out to compare the expression of more than 7,000 gene in the amygdala, cingulate cortex, striatum and cerebellum dis- closed down-regulation of the catalytic subunit PP2A C in AD [57]. This has been further corroborated by quantitative TaqMan PCR showing reduced PP2A C mRNA expression levels in the hippocampus, but not in the frontal cortex, in AD cases with disease progression Fig. (1). PubMed:22299660

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

Out-Edges 2

r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Deficits in PP2A activity are in line with the reported down-regulation of PP2A catalytic C subunit at the gene (Loring et al.,2001), mRNA (Vogelsberg-Ragaglia et al.,2001) and protein (Sontag et al.,2004b) expression levels in AD. PubMed:24653673

Appears in Networks:

r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Decreased mRNA levels of PP2A C have been reported in the CA3 region of AD hippocampus by in situ RNA hybridisation [56]. Moreover, microarray RNA analysis carried out to compare the expression of more than 7,000 gene in the amygdala, cingulate cortex, striatum and cerebellum dis- closed down-regulation of the catalytic subunit PP2A C in AD [57]. This has been further corroborated by quantitative TaqMan PCR showing reduced PP2A C mRNA expression levels in the hippocampus, but not in the frontal cortex, in AD cases with disease progression Fig. (1). PubMed:22299660

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.