a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a)

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PubMed:30126037

In 15-month-old mice with heavy Abeta deposition and phosphorylated tau, but lacking NFT pathology (Orr et al., 2014), Cdkn2a expression was not elevated (Figure 4e). These data indicate that Cdkn2a expression was neither a response to general protein accumulation, nor to pre-NFT tau pathology, but instead required the presence of NFTs

Related Edges 2

• a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a)
• p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a)

Confidence

High

MeSH

Cerebral Cortex

MeSH

Hippocampus

MeSH

Alzheimer Disease

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