a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex"))

View Subject View Object

PubMed:24561250

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008)

Related Edges 3

• a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis)
• a(CHEBI:"amyloid-beta") decreases a(GO:lysosome)
• bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex"))

Cell Ontology (CL)

microglial cell

Confidence

High

NeuroMMSigDB

Amyloidogenic subgraph

NeuroMMSigDB

Endosomal lysosomal subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---