Endosomal lysosomal subgraph

Name: Endosomal lysosomal subgraph
Namespace Keyword: Subgraph
Namespace: NeuroMMSigDB
Namespace Version: 1.0.3
Namespace URL: https://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno

Sample Annotated Edges 2

a(CHEBI:"amyloid-beta") decreases a(GO:lysosome) View Subject | View Object

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:

The role of inflammasome in Alzheimer’s disease v1.0.3

Annotations

Cell Ontology (CL): microglial cell
Confidence: High
NeuroMMSigDB: Amyloidogenic subgraph
NeuroMMSigDB: Endosomal lysosomal subgraph

a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:

The role of inflammasome in Alzheimer’s disease v1.0.3

Annotations

Cell Ontology (CL): microglial cell
Confidence: High
NeuroMMSigDB: Amyloidogenic subgraph
NeuroMMSigDB: Endosomal lysosomal subgraph

Showing 2 of 2 edges

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.