bp(GO:"neuron death") association p(HGNC:SH3GL2)

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PubMed:30444369

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1

Related Edges 6

• bp(GO:"neuron projection development") association p(HGNC:SH3GL2)
• bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2)
• p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1))
• p(HGNC:SH3GL2) association bp(GO:"neuron projection development")
• p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity")
• p(HGNC:SH3GL2) association bp(GO:"neuron death")

MeSH

Neurons

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