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p(HGNC:SH3GL2)

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Entity

Name
SH3GL2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease v1.0.0

In-Edges 4

bp(GO:"neuron death") association p(HGNC:SH3GL2) View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

bp(GO:"neuron projection development") association p(HGNC:SH3GL2) View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2) View Subject | View Object

The second ABAD-related protein, endophilin-1 (Ep-1), is a member of a family of proteins that are responsible for synaptic vesicle endocytosis, mitochondrial function, and receptor trafficking. 110 This family of proteins has been implicated in a number of neurodegenerative diseases, 111 including in AD where it is overexpressed PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

Out-Edges 6

p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") View Subject | View Object

The second ABAD-related protein, endophilin-1 (Ep-1), is a member of a family of proteins that are responsible for synaptic vesicle endocytosis, mitochondrial function, and receptor trafficking. 110 This family of proteins has been implicated in a number of neurodegenerative diseases, 111 including in AD where it is overexpressed PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

The second ABAD-related protein, endophilin-1 (Ep-1), is a member of a family of proteins that are responsible for synaptic vesicle endocytosis, mitochondrial function, and receptor trafficking. 110 This family of proteins has been implicated in a number of neurodegenerative diseases, 111 including in AD where it is overexpressed PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SH3GL2) association bp(GO:"neuron projection development") View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SH3GL2) association bp(GO:"neuron death") View Subject | View Object

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1 PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.