p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity")

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PubMed:30444369

This results in the activation of mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 114 which then activates a cascade of kinases that eventually leads to the translocation of JNK to the nucleus or other target sites to phosphorylate downstream effectors, thereby affecting significant aspects of neuronal function such as neurite outgrowth, mitochondrial function, synaptic plasticity and apoptosis. 1

Related Edges 6

• bp(GO:"neuron death") association p(HGNC:SH3GL2)
• bp(GO:"neuron projection development") association p(HGNC:SH3GL2)
• bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2)
• p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1))
• p(HGNC:SH3GL2) association bp(GO:"neuron projection development")
• p(HGNC:SH3GL2) association bp(GO:"neuron death")

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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