a(CHEBI:cilostazol) increases bp(GO:macroautophagy)

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PubMed:30116051

Cilostazol (a phosphodiesterase 3 inhibitor) clears Aβ42 from neuronal cell lines by promoting autophagy, upregulating beclin 1, ATG5 and LC3, downregulating mTORC1 and inducing lysosomal cathepsin B; these actions of cilostazol involve activation of SIRT1 as well as upstream Tyr172 phosphorylation of AMPK 108,162,163 .

Related Edges 8

• a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42")
• a(CHEBI:cilostazol) increases p(HGNC:BECN1)
• a(CHEBI:cilostazol) increases p(HGNC:ATG5)
• a(CHEBI:cilostazol) increases p(HGNC:MAP1LC3A)
• a(CHEBI:cilostazol) decreases p(FPLX:mTORC1)
• a(CHEBI:cilostazol) increases p(HGNC:CTSB)
• a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1))
• a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172))

MeSH

Dopaminergic Neurons

MeSH

Machado-Joseph Disease

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