a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death")

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PubMed:30126037

NFT containing neurons upregulated genes involved in cell survival and viability, inflammation, cell cycle progression and molecular transport and downregulated apoptosis, necrosis and cell death pathways (Figure 1a). NFkB, a pro-survival master transcriptional regulator of inflammation, was the highest predicted upstream regulator of the NFT-gene expression profile. In agreement with inflammatory activation, other predicted upstream regulators included IFNG, TNF, TLR4, IL1B and CXCL1 (Figure 1b)

Related Edges 11

• a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival")
• a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response")
• a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle")
• a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process")
• a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis)
• a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1)
• a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG)
• a(GO:"neurofibrillary tangle") increases p(HGNC:TNF)
• a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4)
• a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B)
• a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1)

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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